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KMID : 0363320120330040429
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Journal of Korean Oriental Internal Medicine
2012 Volume.33 No. 4 p.429 ~ p.437
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The Effects of Salvia miltiorrhiza on High Fat Diet-induced Obese Diabetic Mouse Model
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Choi Seon-Wook
Kim Dong-Hoon
Choi Seung-Bum
Park Geun-Hee
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Abstract
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Objectives : Obesity is an important cause of diabetes, and lipotoxicity causes insulin resistance. In this study, we investigated the effects of Salvia miltiorrhiza on high fat diet-induced obese type 2 diabetic mouse models.
Methods : Diabetes was induced in ICR male mouse (23~25 g) with Surwit's high fat, high sucrose diet. Mice were divided into 4 groups (n=10) of normal, control, Salvia miltiorrhiza, and metformin. After 8 weeks, body weight, OGTT, fructosamine, lipid profile, serum level of adiponectin and leptin, epididymal fat pad, liver weight and epididymal adipocyte size were measured.
Results : Salvia miltiorrhiza significantly reduced oral glucose tolerance levels, fructosamine serum level, epididymal fat weight, and epididymal adipocyte size. Salvia miltiorrhiza also increased HDL-cholesterol, adiponectin and leptin serum levels.
Conclusions : These results show that Salvia miltiorrhiza improves insulin resistance. Therefore we suggest that Salvia miltiorrhiza would be an effective treatment for obese type 2 diabetic patients.
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KEYWORD
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Salvia miltiorrhiza, insulin resistance, type 2 diabetes, obesity
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